SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands
J.S. Hardwick, S. Dhir, A. Kirchner, A. Simeone, S.F. Flynn, J.M. Edgerton, R. de Cesaris Araujo Tavares, I. Esain Garcia, D. Tannahill, P. Golder, Jack M. Monahan, W.S. Gosal, S. Balasubramanian
Proceedings of the National Academy of Sciences, 2025
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Y. Baker, C. Thorpe, J. Chen, L. Poller, L. Cox, P. Kumar, W.F. Lim, L. Lie, G. McClorey, S. Epple, D. Singleton, M. McDonough, J.S. Hardwick, K. Christensen, M. Wood, J.P. Hall, A.H. El-Sagheer, T. Brown
Nature Communications, 2022
2′-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis.
J.S. Hardwick*, M. M. Haugland*, A.H. El-Sagheer, D. Ptchelkine, F.R. Beierlein, A.N. Lane, T. Brown, J.E. Lovett, E.A. Anderson
Nucleic Acids Research, vol. 48, no. 6, 2830–2840, 2020
Epigenetic modifications of cytosine: biophysical properties, regulation, and function in mammalian DNA.
J.S. Hardwick, A.N. Lane, and T. Brown
BioEssays, 1700199, 2018
Stoichiometry and dispersity of DNA nanostructures using photobleaching pair-correlation analysis.
A.A. Hariri, G.D. Hamblin, J.S. Hardwick, R. Godin, J.-F. Desjardins, P.W. Wiseman, H.F. Sleiman, and G. Cosa
Bioconjugate Chemistry, vol. 28, no. 9, pp. 2340–2349, 2017
5-Formylcytosine does not change the global structure of DNA.
J.S. Hardwick*, D.Ptchelkine*, A.H. El-Sagheer, I. Tear, D. Singleton, S.E.V. Phillips, A.N. Lane, and T. Brown
Nature Structural & Molecular Biology, vol. 24, no. 6, pp. 544–552, 2017